Different role of circulating myeloid-derived suppressor cells in patients with multiple myeloma undergoing autologous stem cell transplantation

The aim of this study is to evaluate the prognostic impact of myeloid-derived suppressor cells (MDSCs) in multiple myeloma (MM) in the context of autologous stem cell transplantation (ASCT). Peripheral blood samples were collected for measuring monocytic (M-) MDSCs (CD14 HLA-DR ) and early-stage (E-...

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Veröffentlicht in:	Journal for immunotherapy of cancer 2019-02, Vol.7 (1), p.35-35, Article 35
Hauptverfasser:	Lee, Sung-Eun, Lim, Ji-Young, Kim, Tae Woo, Ryu, Da-Bin, Park, Sung Soo, Jeon, Young-Woo, Yoon, Jae-Ho, Cho, Byung-Sik, Eom, Ki-Seong, Kim, Yoo-Jin, Kim, Hee-Je, Lee, Seok, Cho, Seok-Goo, Kim, Dong-Wook, Lee, Jong Wook, Min, Chang-Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Antineoplastic Agents, Alkylating - therapeutic use Autologous stem cell transplantation Bioinformatics Cancer Cancer therapies Care and treatment Chemotherapy Colony-stimulating factor 1 receptor Development and progression Disease Female Flow cytometry Genotype & phenotype Humans Immunotherapy Lymphocytes Male Melphalan - therapeutic use Middle Aged Multiple myeloma Multiple Myeloma - immunology Multiple Myeloma - therapy Myeloid-derived suppressor cells Myeloid-Derived Suppressor Cells - immunology Phenotypes Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - immunology Software Stem Cell Transplantation Stem cells T cells Transplantation, Autologous Transplants & implants
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Beschreibung
Zusammenfassung:	The aim of this study is to evaluate the prognostic impact of myeloid-derived suppressor cells (MDSCs) in multiple myeloma (MM) in the context of autologous stem cell transplantation (ASCT). Peripheral blood samples were collected for measuring monocytic (M-) MDSCs (CD14 HLA-DR ) and early-stage (E-) MDSCs (Lin HLA-DR CD33 CD11b ) before and after ASCT. Clinical outcomes following ASCT differed according to the frequency of each MDSC phenotype. In the pre-ASCT analyses, lower M-MDSCs (
ISSN:	2051-1426 2051-1426
DOI:	10.1186/s40425-018-0491-y