Analysis of subgingival microbiota in monozygotic twins with different severity and progression risk of periodontitis

The study aims to reveal the composition of subgingival bacteria in monozygotic twins with discordant in severity and progression risk of periodontitis. Microbiome analysis indicated that most bacteria were heritable but differed in their abundance and immune response. The dysbiotic bacteria can be considered as risk markers for periodontitis progression. In twins with periodontitis, host genetics influence the heritability of the subgingival flora, but their environment affects the abundance. The dysbiotic flora is a risk marker for the disease and may add new insight to periodontitis classification.