Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles

Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles

PurposeAlopecia areata (AA) is one of the most prevalent autoimmune diseases affecting humans. Given that hair follicles are immune-privileged, autoimmunity can result in disfiguring hair loss. However, the genetic basis for AA in the Taiwanese population remains unknown. Materials and MethodsA geno...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical, cosmetic and investigational dermatology cosmetic and investigational dermatology, 2023-01, Vol.16, p.2597-2612
Hauptverfasser: Yang, Jai-Sing, Liu, Ting-Yuan, Chen, Yu-Chia, Tsai, Shih-Chang, Chiu, Yu-Jen, Liao, Chi-Chou, Tsai, Fuu-Jen
Format: Artikel
Sprache:eng
Schlagworte:
alopecia areata
genome-wide association study
hla genotypes
network analysis
Original Research
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:PurposeAlopecia areata (AA) is one of the most prevalent autoimmune diseases affecting humans. Given that hair follicles are immune-privileged, autoimmunity can result in disfiguring hair loss. However, the genetic basis for AA in the Taiwanese population remains unknown. Materials and MethodsA genome-wide association study was conducted using a cohort of 408 AA cases and 8167 controls. To link variants to gene relationships, we used 882 SNPs (P
ISSN:1178-7015
1178-7015
DOI:10.2147/CCID.S428788