Iron Chelation in Local Infection

Iron Chelation in Local Infection

Iron is an essential element in multiple biochemical pathways in humans and pathogens. As part of the innate immune response in local infection, iron availability is restricted locally in order to reduce overproduction of reactive oxygen species by the host and to attenuate bacterial growth. This ph...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2021-01, Vol.26 (1), p.189
Hauptverfasser: Scott, Cassidy, Arora, Gaurav, Dickson, Kayle, Lehmann, Christian
Format: Artikel
Sprache:eng
Schlagworte:
Binding sites
Chelating agents
Chelation
Deprivation
Glycoproteins
Hemoglobin
Homeostasis
Immune response
Infections
Innate immunity
Iron
Liver
local infection
Metabolism
Neutrophils
Peptides
Physiology
Plasma
Proteins
Reactive oxygen species
Recycling
Review
siderophores
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Zusammenfassung:Iron is an essential element in multiple biochemical pathways in humans and pathogens. As part of the innate immune response in local infection, iron availability is restricted locally in order to reduce overproduction of reactive oxygen species by the host and to attenuate bacterial growth. This physiological regulation represents the rationale for the therapeutic use of iron chelators to support induced iron deprivation and to treat infections. In this review paper we discuss the importance of iron regulation through examples of local infection and the potential of iron chelation in treating infection.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26010189