Plasma cathelicidin and longitudinal lung function in current and former smokers

Cathelicidin (also known as LL-37 in humans) is an antimicrobial peptide secreted by epithelial and immune cells and regulated by vitamin D. The immunological roles of cathelicidin make it a putative biomarker to identify individuals at risk for reduced lung function. The objective of this study is...

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Veröffentlicht in:	PloS one 2019-02, Vol.14 (2), p.e0212628-e0212628
Hauptverfasser:	Burkes, Robert M, Astemborski, Jacquie, Lambert, Allison A, Brown, Todd T, Wise, Robert A, Kirk, Gregory D, Drummond, M Bradley
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African Americans Analysis Antimicrobial Cationic Peptides - blood Biology and Life Sciences Biomarkers - blood Cathelicidins Chronic obstructive lung disease Female Forced Expiratory Volume - physiology Health aspects Humans Longitudinal Studies Lung - physiopathology Male Medicine and Health Sciences Middle Aged Non-Smokers - statistics & numerical data People and places Peptides Physical sciences Predictive Value of Tests Prognosis Prospective Studies Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary function tests Research and Analysis Methods Risk Factors Smokers Smokers - statistics & numerical data Smoking - blood Smoking - immunology Smoking - physiopathology Vitamin D Vitamin D - blood Vitamins
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Zusammenfassung:	Cathelicidin (also known as LL-37 in humans) is an antimicrobial peptide secreted by epithelial and immune cells and regulated by vitamin D. The immunological roles of cathelicidin make it a putative biomarker to identify individuals at risk for reduced lung function. The objective of this study is to determine potential independent associations between low plasma cathelicidin and longitudinal lung function in current or former smokers without COPD. In a nested analysis of 308 participants from an observational cohort study, plasma cathelicidin and serum 25-hydroxy-vitamin D measurements were obtained at baseline, years three and five. The independent association between lowest quartile cathelicidin (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0212628