Copper(II) sulfamate: an efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-ones and thiones

A simple, efficient procedure for the one-pot Biginelli condensation reaction of aldehydes, beta-ketoesters and urea or thiourea employing copper(II) sulfamate as a novel catalyst is described. Compared to the classical Biginelli reaction conditions, the present method has the advantages of good yie...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2009-02, Vol.14 (2), p.763-770
Hauptverfasser:	Liu, Chen-Jiang, Wang, Ji-De
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemistry Acids Aldehydes - chemistry Biginelli reaction Catalysis Copper Copper - chemistry Copper(II) sulfamate Dihydropyrimidinones Molecular Structure Pyrimidinones - chemical synthesis Pyrimidinones - chemistry Solvents Sulfonic Acids - chemistry Thiones - chemical synthesis Thiones - chemistry Urea - chemistry
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Beschreibung
Zusammenfassung:	A simple, efficient procedure for the one-pot Biginelli condensation reaction of aldehydes, beta-ketoesters and urea or thiourea employing copper(II) sulfamate as a novel catalyst is described. Compared to the classical Biginelli reaction conditions, the present method has the advantages of good yields, short reaction times and experimental simplicity.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules14020763