Oxidative stress status in nutritionally stunted children

Oxidative stress is the imbalance between pro-oxidants and antioxidants resulting in irreversible cell damage. To assess the oxidative stress status in a sample of Egyptian malnourished stunted children and investigate the relations between oxidative stress markers and anthropometric measurements. This cross sectional descriptive analytical study was carried out on 50 malnourished stunted children (28 males and 22 females), aged from 6–9years and 50 healthy age and sex-matched controls. Blood oxidative stress biomarkers including catalase (CAT), superoxide dismutase (SOD) malondialdehyde (MDA), plasma glutathione (GSH), total plasma proteins, total anti-oxidant capacity (TAC), copper (Cu), zinc (Zn), and vitamin C were measured in patients and controls. Socio-economic status was assessed for patients. Body weight and height were measured and body mass index (BMI) was calculated. Patients were classified according to their height for age Z-scores (HAZ) into moderate and severe stunted. Nutritionally stunted children showed significantly lower levels of the blood oxidative stress biomarkers including, CAT, SOD, plasma GSH, total plasma proteins, Cu, Zn and vitamin C and significantly higher levels of MDA compared with controls (p