Deficiency in infiltration of CD8/CD3 positive lymphocytes and macrophages plays a role in lip carcinogenesis: an immunohistochemical study

•Macrophages (CD68+) migrate into the tumor and interact with CD3, CD8 and CD20.•CD20 affects perineural invasion and histological gradation.•More aggressive tumors have lower amounts of CD20. To evaluate the immunoexpression profile for CD8, CD3, CD20 and CD68 in the process and carcinogenesis of C...

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Veröffentlicht in:	Brazilian journal of otorhinolaryngology 2024-03, Vol.90 (2), p.101379, Article 101379
Hauptverfasser:	Magalhães, Iana Aragão, Costa, Gabriella Alves Juliao, Borges, Marcela Maria Fontes, Carlos, Anna Clara Aragão Matos, Mesquita, Karine Cestaro, Arruda, Larissa Mont´Alverne de, Cunha, Maria do Perpétuo Socorro Saldanha, Sousa, Fabrício Bitu, Silva, Paulo Goberlânio de Barros
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenesis Carcinoma CD8-Positive T-Lymphocytes Humans Lip Lip neoplasms Lymphocytes Macrophages Original OTORHINOLARYNGOLOGY Prognosis Tumor microenvironment Tumor-infiltrating
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Zusammenfassung:	•Macrophages (CD68+) migrate into the tumor and interact with CD3, CD8 and CD20.•CD20 affects perineural invasion and histological gradation.•More aggressive tumors have lower amounts of CD20. To evaluate the immunoexpression profile for CD8, CD3, CD20 and CD68 in the process and carcinogenesis of Carcinoma of the vermilion lip. Average cell count with positive expression for CD3, CD8, CD20 and CD68. The CD8/CD3 ratio calculated in the region was based on the percentage of positive cells in a total of malignant cells. Kruska-Wallis/Dunn, Mann-Whitney and Spearman correlation tests (SPSS, p
ISSN:	1808-8694 1808-8686 1808-8686
DOI:	10.1016/j.bjorl.2023.101379