SARS-CoV-2 Subgenomic RNAs: Characterization, Utility, and Perspectives

SARS-CoV-2, the etiologic agent at the root of the ongoing COVID-19 pandemic, harbors a large RNA genome from which a tiered ensemble of subgenomic RNAs (sgRNAs) is generated. Comprehensive definition and investigation of these RNA products are important for understanding SARS-CoV-2 pathogenesis. Th...

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Veröffentlicht in:	Viruses 2021-09, Vol.13 (10), p.1923
1. Verfasser:	Long, Samuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon Coronaviruses COVID-19 COVID-19 - genetics COVID-19 - metabolism Disease transmission Gene Expression - genetics Gene Expression Regulation, Viral - genetics Genome, Viral - genetics Genomes Genomics - methods Humans Identification and classification Metabolism Microscopy Mitochondria Pandemics Proteins Reading Review RNA RNA, Viral - genetics RNA, Viral - metabolism SARS-CoV-2 SARS-CoV-2 - genetics SARS-CoV-2 - pathogenicity Severe acute respiratory syndrome coronavirus 2 sgRNA subgenomic RNA Virus Replication Viruses
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Beschreibung
Zusammenfassung:	SARS-CoV-2, the etiologic agent at the root of the ongoing COVID-19 pandemic, harbors a large RNA genome from which a tiered ensemble of subgenomic RNAs (sgRNAs) is generated. Comprehensive definition and investigation of these RNA products are important for understanding SARS-CoV-2 pathogenesis. This review summarizes the recent progress on SARS-CoV-2 sgRNA identification, characterization, and application as a viral replication marker. The significance of these findings and potential future research areas of interest are discussed.
ISSN:	1999-4915 1999-4915
DOI:	10.3390/v13101923