Sc3.0: revamping and minimizing the yeast genome

[...]the newly synthesized Sc3.0 chromosomes could then be combined into a single yeast to obtain strains with multiple chromosomes [8], or alternatively, these chromosomes could be merged into a single large chromosome [9, 10]. [...]regulatory elements such as promoters and terminators should be replaced by functionally validated but completely artificial sequences, or sequences from other yeast species as proposed for the base Sc3.0 strain. [...]genes can be clustered according to their functionality or arranged based on their chromosomal locations.