DNA methylation profiles in sibling pairs discordant for intrauterine exposure to maternal gestational diabetes

DNA methylation profiles in sibling pairs discordant for intrauterine exposure to maternal gestational diabetes

Intrauterine exposure to hyperglycemia is reported to confer increased metabolic risk in later life, supporting the 'developmental origins of health and disease' hypothesis. Epigenetic alterations are suggested as one of the possible underlying mechanisms. In this study, we compared pairwi...

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Veröffentlicht in:Epigenetics 2017-01, Vol.12 (10), p.825-832
Hauptverfasser: Kim, Eunae, Kwak, Soo Heon, Chung, Hye Rim, Ohn, Jung Hun, Bae, Jae Hyun, Choi, Sung Hee, Park, Kyong Soo, Hong, Joon-Seok, Sung, Joohon, Jang, Hak Chul
Format: Artikel
Sprache:eng
Schlagworte:
Brief Report
dna methylation
epigenome-wide association study
gestational diabetes mellitus
intrauterine environment
siblings
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Zusammenfassung:Intrauterine exposure to hyperglycemia is reported to confer increased metabolic risk in later life, supporting the 'developmental origins of health and disease' hypothesis. Epigenetic alterations are suggested as one of the possible underlying mechanisms. In this study, we compared pairwise DNA methylation differences between siblings whose intrauterine exposure to maternal gestational diabetes (GDM) were discordant. Methylation of peripheral blood DNA of 18 sibling pairs was measured using Infinium HumanMethylation450 BeadChip assays. Of the 465,447 CpG sites analyzed, 12 showed differential methylation (false discovery rate
ISSN:1559-2294
1559-2308
DOI:10.1080/15592294.2017.1370172