Roles of Achieved Levels of Low-Density Lipoprotein Cholesterol and High-Sensitivity C-Reactive Protein on Cardiovascular Outcome in Statin Therapy

In statin therapy, the prognostic role of achieved low-density lipoprotein cholesterol (LDL-C) and high-sensitivity C-reactive protein (hsCRP) in cardiovascular outcomes has not been fully elucidated. A total of 4,803 percutaneous coronary intervention (PCI)-naïve patients who prescribed moderate in...

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Veröffentlicht in:	Cardiovascular therapeutics 2019, Vol.2019 (2019), p.1-10
Hauptverfasser:	Lee, Eunmi, Seo, Hong Seog, Park, Chang G., Kim, Eung Ju, Kim, Jin Won, Choi, Cheol Ung, Na, Jin Oh, Choi, Byoung Geol, Lee, Yuchang, Hyun, Myung Han, Rha, Seung-Woon
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Angina pectoris Angioplasty Anti-Inflammatory Agents - adverse effects Anti-Inflammatory Agents - therapeutic use Apolipoproteins Atherosclerosis Atrial fibrillation Biomarkers - blood C-reactive protein C-Reactive Protein - metabolism Cardiac patients Cardiology Cardiovascular disease Cardiovascular Diseases - blood Cardiovascular Diseases - diagnosis Cardiovascular Diseases - mortality Cardiovascular Diseases - prevention & control Care and treatment Cholesterol Cholesterol, LDL - blood Clinical outcomes Clinical trials Clopidogrel Comparative analysis Coronary vessels Diabetes Disease prevention Down-Regulation Dyslipidemias - blood Dyslipidemias - diagnosis Dyslipidemias - drug therapy Dyslipidemias - mortality Female Heart Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Incidence Inflammation Inflammation - blood Inflammation - diagnosis Inflammation - drug therapy Inflammation - mortality Laboratories Lipoproteins Low density lipoproteins Male Middle Aged Mortality Population Registries Risk Assessment Risk Factors Statins Time Factors Transluminal angioplasty Treatment Outcome Trimetazidine
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Zusammenfassung:	In statin therapy, the prognostic role of achieved low-density lipoprotein cholesterol (LDL-C) and high-sensitivity C-reactive protein (hsCRP) in cardiovascular outcomes has not been fully elucidated. A total of 4,803 percutaneous coronary intervention (PCI)-naïve patients who prescribed moderate intensity of statin therapy were followed up. Total and each component of major adverse cardiovascular events (MACE) according to LDL-C and hsCRP quartiles were compared. The incidence of 5-year total MACEs in the highest quartile group according to the followed-up hsCRP was higher than that in the lowest quartile (hazard ratio (HR) = 2.16, p
ISSN:	1755-5914 1755-5922
DOI:	10.1155/2019/3824823