Establishment of a Strong Link Between Smoking and Cancer Pathogenesis through DNA Methylation Analysis

Establishment of a Strong Link Between Smoking and Cancer Pathogenesis through DNA Methylation Analysis

Smoking is a well-documented risk factor in various cancers, especially lung cancer. In the current study, we tested the hypothesis that abnormal DNAm loci associated with smoking are enriched in genes and pathways that convey a risk of cancer by determining whether smoking-related methylated genes...

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Veröffentlicht in:Scientific reports 2017-05, Vol.7 (1), p.1811-13, Article 1811
Hauptverfasser: Ma, Yunlong, Li, Ming D.
Format: Artikel
Sprache:eng
Schlagworte:
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Biomarkers
Blood
Computational Biology - methods
Disease Susceptibility
DNA Methylation
Epigenesis, Genetic
Gene Expression Profiling
Gene Regulatory Networks
Health risks
Humanities and Social Sciences
Humans
Lung cancer
Models, Biological
multidisciplinary
Neoplasms - etiology
Neoplasms - metabolism
Risk factors
Science
Science (multidisciplinary)
Signal Transduction
Smoking
Smoking - adverse effects
Studies
Transcriptome
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Zusammenfassung:Smoking is a well-documented risk factor in various cancers, especially lung cancer. In the current study, we tested the hypothesis that abnormal DNAm loci associated with smoking are enriched in genes and pathways that convey a risk of cancer by determining whether smoking-related methylated genes led to enrichment in cancer-related pathways. We analyzed two sets of smoking-related methylated genes from 28 studies originating from blood and buccal samples. By analyzing 320 methylated genes from 26 studies on blood samples (N = 17,675), we found 57 enriched pathways associated with different types of cancer (FDR 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-01856-4