Effect of silibinin on GAS6/sAXL and JAK/STAT pathways in human cholangiocarcinoma cell line

Effect of silibinin on GAS6/sAXL and JAK/STAT pathways in human cholangiocarcinoma cell line

Cholangiocarcinoma (CCA) is a highly heterogeneous biliary malignant tumor. Studies have demonstrated that JAK/STAT signaling is activated in many types of cancer. In addition, JAK/STAT is activated downstream of AXL, and the AXL receptor is activated by its ligand, GAS6. In this study, we investiga...

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Veröffentlicht in:Türk biyokimya dergisi 2024-09, Vol.49 (5), p.637-646
Hauptverfasser: Caliskan, Zehra Nur, Ozel Yetkin, Merve, Baskol, Mevlut, Baskol, Gulden
Format: Artikel
Sprache:eng
Schlagworte:
apoptosis
cholangiocarcinoma
GAS6/AXL signaling pathway
JAK/STAT signaling pathway
silibinin
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Zusammenfassung:Cholangiocarcinoma (CCA) is a highly heterogeneous biliary malignant tumor. Studies have demonstrated that JAK/STAT signaling is activated in many types of cancer. In addition, JAK/STAT is activated downstream of AXL, and the AXL receptor is activated by its ligand, GAS6. In this study, we investigated the anticarcinogenic effect of silibinin and its relationship with the GAS6/AXL ve JAK/STAT pathway in the human EGI-1 cell line.
ISSN:1303-829X
1303-829X
DOI:10.1515/tjb-2022-0275