Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation

Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation

JQ1 is a BET-bromodomain inhibitor that has immunomodulatory effects. However, the precise molecular mechanism that JQ1 targets to elicit changes in antibody production is not understood. Our results show that JQ1 induces apoptosis, reduces cell proliferation, and as a consequence, inhibits antibody...

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Veröffentlicht in:Cell reports (Cambridge) 2020-10, Vol.33 (3), p.108290-108290, Article 108290
Hauptverfasser: Kong, Isabella Y., Rimes, Joel S., Light, Amanda, Todorovski, Izabela, Jones, Sarah, Morand, Eric, Knight, Deborah A., Bergman, Ylva E., Hogg, Simon J., Falk, Hendrik, Monahan, Brendon J., Stupple, Paul A., Street, Ian P., Heinzel, Susanne, Bouillet, Philippe, Johnstone, Ricky W., Hodgkin, Philip D., Vervoort, Stephin J., Hawkins, Edwin D.
Format: Artikel
Sprache:eng
Schlagworte:
B cells
cellular immunology
epigenetics
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Zusammenfassung:JQ1 is a BET-bromodomain inhibitor that has immunomodulatory effects. However, the precise molecular mechanism that JQ1 targets to elicit changes in antibody production is not understood. Our results show that JQ1 induces apoptosis, reduces cell proliferation, and as a consequence, inhibits antibody-secreting cell differentiation. ChIP-sequencing reveals a selective displacement of Brd4 in response to acute JQ1 treatment (
ISSN:2211-1247
2211-1247
DOI:10.1016/j.celrep.2020.108290