Catalytic System for Cross-Coupling of Heteroaryl Iodides with a Nitronyl Nitroxide Gold Derivative at Room Temperature

Catalytic System for Cross-Coupling of Heteroaryl Iodides with a Nitronyl Nitroxide Gold Derivative at Room Temperature

A simple and highly effective methodology for the cross-coupling of heteroaryl iodides with NN–AuPPh3 at room temperature is reported. The protocol is based on a novel catalytic system consisting of Pd2(dba)3·CHCl3 and the phosphine ligand MeCgPPh having an adamantane-like framework. The present pro...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2023-11, Vol.28 (22), p.7661
Hauptverfasser: Zayakin, Igor, Romanenko, Galina, Bagryanskaya, Irina, Ugrak, Bogdan, Fedin, Matvey, Tretyakov, Evgeny
Format: Artikel
Sprache:eng
Schlagworte:
cross-coupling
Free radicals (Chemistry)
Gold
Ligands
Magnetism
nitronyl nitroxides
organic gold compounds
stable radicals
Temperature
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Beschreibung
Zusammenfassung:A simple and highly effective methodology for the cross-coupling of heteroaryl iodides with NN–AuPPh3 at room temperature is reported. The protocol is based on a novel catalytic system consisting of Pd2(dba)3·CHCl3 and the phosphine ligand MeCgPPh having an adamantane-like framework. The present protocol was found to be well compatible with various heteroaryl iodides, thus opening new horizons in directed synthesis of functionalized nitronyl nitroxides and high-spin molecules.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28227661