Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder

Bipolar disorder (BD) is a multifactorial condition. Several signaling pathways affect development of this disorder. With the purpose of exploring the role of vitamin D receptor (VDR) signaling in this disorder, we measured expression of selected mRNA coding genes and long non-coding RNAs (lncRNAs)...

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Veröffentlicht in:	BMC psychiatry 2022-03, Vol.22 (1), p.178-178, Article 178
Hauptverfasser:	Eghtedarian, Reyhane, Ghafouri-Fard, Soudeh, Bouraghi, Hamid, Hussen, Bashdar Mahmud, Arsang-Jang, Shahram, Taheri, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism Alfacalcidol Biological markers Bipolar disorder Bipolar Disorder - genetics Calcifediol Diagnosis Drug therapy Female Genetic aspects Genetic regulation Health aspects Humans LINC00346 LINC00511 MALAT1 Male Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction SNHG6 VDR Vitamin D
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Zusammenfassung:	Bipolar disorder (BD) is a multifactorial condition. Several signaling pathways affect development of this disorder. With the purpose of exploring the role of vitamin D receptor (VDR) signaling in this disorder, we measured expression of selected mRNA coding genes and long non-coding RNAs (lncRNAs) in this pathway in patients versus normal subjects. We measured expression of VDR-associated lncRNAs and mRNAs (SNHG6, MALAT1, Linc00511, Linc00346, VDR and CYP27B1) in the peripheral blood of BD patients vs. healthy individuals. Expression of SNHG6 was significantly higher in cases vs. controls (Posterior beta = 1.29, P value
ISSN:	1471-244X 1471-244X
DOI:	10.1186/s12888-022-03811-8