Suppression of the Peripheral Immune System Limits the Central Immune Response Following Cuprizone-Feeding: Relevance to Modelling Multiple Sclerosis

Suppression of the Peripheral Immune System Limits the Central Immune Response Following Cuprizone-Feeding: Relevance to Modelling Multiple Sclerosis

Cuprizone (CPZ) preferentially affects oligodendrocytes (OLG), resulting in demyelination. To investigate whether central oligodendrocytosis and gliosis triggered an adaptive immune response, the impact of combining a standard (0.2%) or low (0.1%) dose of ingested CPZ with disruption of the blood br...

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Veröffentlicht in:Cells (Basel, Switzerland) Switzerland), 2019-10, Vol.8 (11), p.1314
Hauptverfasser: Sen, Monokesh K, Almuslehi, Mohammed S M, Gyengesi, Erika, Myers, Simon J, Shortland, Peter J, Mahns, David A, Coorssen, Jens R
Format: Artikel
Sprache:eng
Schlagworte:
Adaptive immunity
Antigens
Atrophy
bioinformatics
Blood-brain barrier
Brain research
CD4 antigen
CD8 antigen
Cuprizone
Demyelination
Gliosis
histology
Immune response
Immune system
inside-out
mitochondria
Multiple sclerosis
Oligodendrocytes
oligodendrocytosis
outside-in
Pertussis
Pertussis toxin
Proteins
Proteomes
Spleen
Structure-function relationships
top-down proteomics
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Zusammenfassung:Cuprizone (CPZ) preferentially affects oligodendrocytes (OLG), resulting in demyelination. To investigate whether central oligodendrocytosis and gliosis triggered an adaptive immune response, the impact of combining a standard (0.2%) or low (0.1%) dose of ingested CPZ with disruption of the blood brain barrier (BBB), using pertussis toxin (PT), was assessed in mice. 0.2% CPZ(±PT) for 5 weeks produced oligodendrocytosis, demyelination and gliosis marked splenic atrophy (37%)
ISSN:2073-4409
2073-4409
DOI:10.3390/cells8111314