COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study

Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability in solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort of 488 SOTR, nonvaccinated (n = 394) and vaccinated (...

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Veröffentlicht in:	Scientific reports 2024-12, Vol.14 (1), p.30021-13, Article 30021
Hauptverfasser:	Infante-Domínguez, Carmen, Salto-Alejandre, Sonsoles, Álvarez-Marín, Rocío, Sabé, Nuria, Ramos-Martínez, Antonio, Moreno, Asunción, Ferreira de Moraes, Kamilla, Palacios-Baena, Zaira R., Muñoz, Patricia, Fernández-Ruiz, Mario, Blanes, Marino, Fariñas, Carmen, Vidal, Elisa, Merino de Lucas, Esperanza, Halpern, Márcia, Hernández-Gallego, Román, Bassetti, Matteo, Mularoni, Alessandra, Gutiérrez-Dalmau, Alex, Rinaldi, Matteo, Jiménez-Jorge, Silvia, Bodro, Marta, Aranha-Camargo, Luis Fernando, Valerio, Maricela, Sánchez-Céspedes, Javier, Gutiérrez-Gutiérrez, Belén, Giannella, Maddalena, Rodríguez-Baño, Jesús, Pachón, Jerónimo, Cordero, Elisa
Format:	Artikel
Sprache:	eng
Schlagworte:	692/1807 692/308 692/699 Aged Clinical phenotypes COVID-19 COVID-19 - epidemiology COVID-19 - mortality COVID-19 - prevention & control COVID-19 - virology COVID-19 vaccines COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - immunology Female Health risks Humanities and Social Sciences Humans Male Middle Aged Mortality Mortality risk Multicenter cohort study multidisciplinary Organ Transplantation - adverse effects Patients Phenotype Phenotypes Population studies SARS-CoV-2 - immunology SARS-CoV-2 - isolation & purification Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Solid organ transplant recipients Transplant Recipients - statistics & numerical data Transplants & implants Vaccination
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Zusammenfassung:	Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability in solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort of 488 SOTR, nonvaccinated (n = 394) and vaccinated (n = 94) against SARS-CoV-2, we evaluated 16 demographic, clinical, analytical, and radiological variables to identify the clinical phenotypes A, B, and C. The median age was 61.0 (51–69) years, 330 (67.6%) and 158 (32.4%) were men and women, respectively, 415 (85%) had pneumonia, and 161 (33%) had SpO 2
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-024-81099-2