Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum

DNA methylation (DNAm) levels lend themselves for defining an epigenetic biomarker of aging known as the ‘epigenetic clock’. Our genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identifies five significant ( P

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Bibliographische Detailangaben
Veröffentlicht in:	Nature communications 2016-02, Vol.7 (1), p.10561-10561, Article 10561
Hauptverfasser:	Lu, Ake T., Hannon, Eilis, Levine, Morgan E., Hao, Ke, Crimmins, Eileen M., Lunnon, Katie, Kozlenkov, Alexey, Mill, Jonathan, Dracheva, Stella, Horvath, Steve
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/43 631/208/205/2138 631/378/1689 631/378/2584 631/378/2632/1368 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Aging Cell Line Cerebellum - physiology Epigenesis, Genetic - physiology Gene Expression Regulation - physiology Genetic Variation Genome-Wide Association Study Humanities and Social Sciences Humans Linkage Disequilibrium MTOR Associated Protein, LST8 Homolog multidisciplinary Science Science (multidisciplinary)
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Beschreibung
Zusammenfassung:	DNA methylation (DNAm) levels lend themselves for defining an epigenetic biomarker of aging known as the ‘epigenetic clock’. Our genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identifies five significant ( P
ISSN:	2041-1723 2041-1723
DOI:	10.1038/ncomms10561