P3.09: Treatment with Tocilizumab Improves Arterial Function in Rheumatoid Arthritis: A 6-Months Pilot Study

P3.09: Treatment with Tocilizumab Improves Arterial Function in Rheumatoid Arthritis: A 6-Months Pilot Study

Background Endothelial function and arterial stiffness are significantly worse in rheumatoid arthritis (RA) compared to healthy controls in part due to the high-grade inflammation. In non-RA subjects, elevated serum levels of interleukin (IL)-6 are associated with accelerated atherosclerosis. Object...

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Veröffentlicht in:Artery research 2011, Vol.5 (4), p.158-159
Hauptverfasser: Protogerou, A. D., Zampeli, E., Fragiadaki, K., Stamatelopoulos, K., Panopoulos, S., Papamichael, C. M., Sfikakis, P. P.
Format: Artikel
Sprache:eng
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Conference Abstract
Monoclonal antibodies
Pilot projects
Rheumatoid arthritis
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Zusammenfassung:Background Endothelial function and arterial stiffness are significantly worse in rheumatoid arthritis (RA) compared to healthy controls in part due to the high-grade inflammation. In non-RA subjects, elevated serum levels of interleukin (IL)-6 are associated with accelerated atherosclerosis. Objectives: To examine whether therapeutic blockade of IL-6 receptor by tocilizumab in patients with active RA improves endothelial dysfunction and increases arterial elasticity. Methods In 11 non-diabetic women with RA (aged 44.5±9.9 years, mean+SD) without concomitant cardiovascular disease, who had documented endothelial dysfunction (defined by flow mediated dilatation (FMD) of the brachial artery:
ISSN:1872-9312
1876-4401
1876-4401
DOI:10.1016/j.artres.2011.10.044