VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia

Aim. The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia. Material and Method. One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN) and 111 controls (negative for both HPV testing a...

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Veröffentlicht in:	Analytical cellular pathology (Amsterdam) 2016-01, Vol.2016 (2016), p.1-5
Hauptverfasser:	Muresan, Daniel, Cotutiu, Paul, Petrisor, Felicia Maria, Popp, Radu A., Dumitras, Diana Elena, Rotar, Ioana Cristina, Stamatian, Florin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Cervical Intraepithelial Neoplasia - genetics Female Genetic Predisposition to Disease Humans Polymorphism, Single Nucleotide - genetics Uterine Cervical Neoplasms - genetics Vascular Endothelial Growth Factor A - genetics
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Zusammenfassung:	Aim. The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia. Material and Method. One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN) and 111 controls (negative for both HPV testing and cytology). For each patient a single visit was scheduled when colposcopy was performed. From cervical specimen, cytology and HPV testing were performed and from peripheral blood VEGF +936 genotyping was determined. For statistical analysis purposes OR and chi-square were used at a level of significance of
ISSN:	2210-7177 2210-7185
DOI:	10.1155/2016/6074275