Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1

Genetic, epigenetic, and environmental factors contribute to the multifactorial disorder progressive supranuclear palsy (PSP). Here, we study epigenetic changes by genome-wide analysis of DNA from postmortem tissue of forebrains of patients and controls and detect significant ( P

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature communications 2018-07, Vol.9 (1), p.2929-12, Article 2929
Hauptverfasser:	Weber, Axel, Schwarz, Sigrid C., Tost, Jörg, Trümbach, Dietrich, Winter, Pia, Busato, Florence, Tacik, Pawel, Windhorst, Anita C., Fagny, Maud, Arzberger, Thomas, McLean, Catriona, van Swieten, John C., Schwarz, Johannes, Vogt Weisenhorn, Daniela, Wurst, Wolfgang, Adhikary, Till, Dickson, Dennis W., Höglinger, Günter U., Müller, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	45/22 45/23 45/61 45/77 45/90 631/208/176/1988 631/208/212/177 631/378/2584 692/617/375/365 82/80 Aged Aged, 80 and over Antisense DNA CpG islands Deoxyribonucleic acid Dlx1 protein DNA DNA fingerprinting DNA methylation DNA Methylation - genetics Environmental changes Environmental factors Epigenesis, Genetic - genetics Epigenetics Female Gene expression Genes Genomes Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humanities and Social Sciences Humans Life Sciences Male multidisciplinary Paralysis Pathogenesis Progressive supranuclear palsy Proteins Science Science (multidisciplinary) Substantia grisea Supranuclear Palsy, Progressive - genetics Supranuclear Palsy, Progressive - pathology Tau protein tau Proteins - genetics tau Proteins - metabolism Transcription Transcription Factors - genetics Transcription Factors - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Genetic, epigenetic, and environmental factors contribute to the multifactorial disorder progressive supranuclear palsy (PSP). Here, we study epigenetic changes by genome-wide analysis of DNA from postmortem tissue of forebrains of patients and controls and detect significant ( P
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-018-05325-y