Oxidized low density lipoprotein, stem cells, and atherosclerosis

Oxidized low density lipoprotein (ox-LDL), a risk factor of atherosclerosis, facilitates the formation and vulnerability of atherosclerotic plaque, thus contributing to several clinical complications. Stem cells participate in vascular repair after damage and atherosclerosis is a process of inflamma...

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Veröffentlicht in:Lipids in health and disease 2012-07, Vol.11 (1), p.85-85, Article 85
Hauptverfasser: Yang, Hui, Mohamed, Ahmed Salah Salem, Zhou, Sheng-Hua
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Sprache:eng
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Zusammenfassung:Oxidized low density lipoprotein (ox-LDL), a risk factor of atherosclerosis, facilitates the formation and vulnerability of atherosclerotic plaque, thus contributing to several clinical complications. Stem cells participate in vascular repair after damage and atherosclerosis is a process of inflammation accompanied with vascular injury. Researchers have proposed that stem cells participate in the formation of atherosclerotic plaque. Also, because ox-LDL is capable of inducing toxic effects on stem cells, it is reasonable to postulate that ox-LDL promotes the progress of atherosclerosis via acting on stem cells. In the present article, we review the relationship between ox-LDL, stem cells, and atherosclerosis and a portion of the associated mechanisms.
ISSN:1476-511X
1476-511X
DOI:10.1186/1476-511x-11-85