Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease-First Report on the Prospective Relevance of Intrinsic Iron Release

Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease-First Report on the Prospective Relevance of Intrinsic Iron Release

Intrinsic iron release is discussed to have favorable effects in coronary artery disease (CAD). The aim of this study was to evaluate the prognostic relevance of intrinsic iron release in patients with CAD. Intrinsic iron release was based on a definition including hepcidin and soluble transferrin r...

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Veröffentlicht in:Biomolecules (Basel, Switzerland) Switzerland), 2018-08, Vol.8 (3), p.72
Hauptverfasser: Ruhe, Julia, Waldeyer, Christoph, Ojeda, Francisco, Altay, Alev, Schnabel, Renate B, Schäfer, Sarina, Lackner, Karl J, Blankenberg, Stefan, Zeller, Tanja, Karakas, Mahir
Format: Artikel
Sprache:eng
Schlagworte:
Aged
biomarker
Biomarkers
Body mass index
Brain natriuretic peptide
Calcium-binding protein
Cardiomyocytes
Cardiovascular disease
Cardiovascular diseases
Cholesterol
Coronary artery
coronary artery disease
Coronary Artery Disease - diagnosis
Coronary Artery Disease - metabolism
Coronary Artery Disease - mortality
Coronary vessels
Diabetes mellitus
Dyslipidemia
Enzyme-linked immunosorbent assay
Family physicians
Female
Heart attacks
Heart diseases
Heart failure
Hemoglobin
Hepcidin
Hepcidins - metabolism
Homeostasis
Humans
Hypoxia
Immunoassay
Iron
Iron - metabolism
iron release
Laboratories
Male
Medical imaging
Metabolism
Middle Aged
Mortality
Peptides
Prognosis
Receptors, Transferrin - chemistry
Receptors, Transferrin - metabolism
Smoking
Solubility
Transferrin
Troponin
Troponin I
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Zusammenfassung:Intrinsic iron release is discussed to have favorable effects in coronary artery disease (CAD). The aim of this study was to evaluate the prognostic relevance of intrinsic iron release in patients with CAD. Intrinsic iron release was based on a definition including hepcidin and soluble transferrin receptor (sTfR). In a cohort of 811 patients with angiographically documented CAD levels of hepcidin and sTfR were measured at baseline. Systemic body iron release was defined as low levels of hepcidin (
ISSN:2218-273X
2218-273X
DOI:10.3390/biom8030072