A new role for histone demethylases in the maintenance of plant genome integrity

Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes. The catalytic activity of PRC2 is counteracted by Jumonji-type (JMJ) histone demethyl...

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Veröffentlicht in:eLife 2020-10, Vol.9
Hauptverfasser: Antunez-Sanchez, Javier, Naish, Matthew, Ramirez-Prado, Juan Sebastian, Ohno, Sho, Huang, Ying, Dawson, Alexander, Opassathian, Korawit, Manza-Mianza, Deborah, Ariel, Federico, Raynaud, Cecile, Wibowo, Anjar, Daron, Josquin, Ueda, Minako, Latrasse, David, Slotkin, R Keith, Weigel, Detlef, Benhamed, Moussa, Gutierrez-Marcos, Jose
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Sprache:eng
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Zusammenfassung:Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes. The catalytic activity of PRC2 is counteracted by Jumonji-type (JMJ) histone demethylases, which shapes the genomic distribution of H3K27me3. Here, we show that two JMJ histone demethylases in , EARLY FLOWERING 6 (ELF6) and RELATIVE OF EARLY FLOWERING 6 (REF6), play distinct roles in H3K27me3 and H3K27me1 homeostasis. We show that failure to reset these chromatin marks during sexual reproduction results in the transgenerational inheritance of histone marks, which cause a loss of DNA methylation at heterochromatic loci and transposon activation. Thus, Jumonji-type histone demethylases play a dual role in plants by helping to maintain transcriptional states through development and safeguard genome integrity during sexual reproduction.
ISSN:2050-084X
2050-084X
DOI:10.7554/elife.58533