Synthesis of 1-( para -methoxyphenyl)tetrazolyl-Substituted 1,2,3,4-Tetrahydroisoquinolines and Their Transformations Involving Activated Alkynes

Synthesis of 1-( para -methoxyphenyl)tetrazolyl-Substituted 1,2,3,4-Tetrahydroisoquinolines and Their Transformations Involving Activated Alkynes

1-( -Methoxyphenyl)tetrazolyl-substituted 6,7-dimethoxy(6,7-methylenedioxy)-1,2,3,4-tetrahydroisoquinolines formed tetrazolyl-substituted azocines in high yields by using activated alkynes. Unsubstituted at 6,7,8-aromatic fragment 1-tetrazolylisoquinoline interacted in several pathways forming tetra...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2018-11, Vol.23 (11), p.3010
Hauptverfasser: Titov, Alexander A, Samavati, Reza, Alexandrova, Elena V, Borisova, Tatiana N, Dang Thi, Tuyet Anh, Nguyen, Van Tuyen, Le, Tuan Anh, Varlamov, Alexey V, Van der Eycken, Erik V, Voskressensky, Leonid G
Format: Artikel
Sprache:eng
Schlagworte:
activated alkynes
Alkynes
Carbon
Chromatography
cycle expansion
Stevens rearrangement
Substitutes
tetrazolyl benzazocines
tetrazolylisoquinolines
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Zusammenfassung:1-( -Methoxyphenyl)tetrazolyl-substituted 6,7-dimethoxy(6,7-methylenedioxy)-1,2,3,4-tetrahydroisoquinolines formed tetrazolyl-substituted azocines in high yields by using activated alkynes. Unsubstituted at 6,7,8-aromatic fragment 1-tetrazolylisoquinoline interacted in several pathways forming tetrazolyl-substituted azocines, 1-tetrazolyl-1-R-vinylisoquinolines and 3-azaspiro[5.5]undeca-1,7,9-triene.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23113010