Hormonal factors of virus-associated cancer of the cervix uteri

Objective: to study the urinary levels of estrogen metabolites as a diagnostic criterion in patients with cancer of the cervix uteri (CCU) associated with human papillomavirus (HPV) infection to provide a rationale for the use of pathogenetic therapy in the combination treatment of CCU.Subjects and methods. The study enrolled 26 patients with Stages I-IV CCU who were treated at the Department of Gynecology, Tomsk Research Institute of Oncology. The patients’ mean age was 45.6±1.3 years (range 24 to 72 years), the patients of reproductive age ac- counted for 50%. Tumor was staged in accordance with the FIGO classification. Genotyping was carried out on 12 oncotropic types, by estimating the viral load by polymerase chain reaction. Urinary estrogen metabolite levels were measured in all patients.Results. In the female patients, the urinary level of the metabolite 2-OHE1 responsible for normal cell growth was 8.95±2.9 ng/mg, which was significantly below the values in healthy women (19.7±1.2 ng/mg). The level of the metabolite 16