Potassium 6-Oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate

Potassium 6-Oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate

Potassium 6-oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate was synthesized through a multi-step pathway, starting from commercially available 3-iodo-1,2-phenylenediamine. Structure characterization of this new substituted macroc...

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Veröffentlicht in:MolBank 2023-12, Vol.2023 (4), p.M1735
Hauptverfasser: Blouet, Camille, Letast, Stéphanie, Robert, Thomas, Bach, Stéphane, Pinaud, Noël, Joubert, Nicolas, Viaud-Massuard, Marie-Claude, Guillon, Jean, Logé, Cédric, Denevault-Sabourin, Caroline
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Cancer
Chromatography
FDA approval
Human health and pathology
kinase inhibitor
Kinases
Life Sciences
macrocycle
NMR
Nuclear magnetic resonance
Oncology
Phenylenediamine
Pim kinases
Potassium
Proteins
quinoxaline
Quinoxalines
Solvents
Spectrum analysis
Structural analysis
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Zusammenfassung:Potassium 6-oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate was synthesized through a multi-step pathway, starting from commercially available 3-iodo-1,2-phenylenediamine. Structure characterization of this new substituted macrocyclic quinoxaline compound was achieved using 1H NMR, 13C NMR, and HRMS spectral analysis. This new macrocyclic derivative demonstrated submicromolar potency on both Pim-1 and Pim-2 isoforms, with an interesting selectivity profile against a selected panel of human kinases.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1735