Prophylactic effects of Ixora coccinea leaf on the haematological, biochemical, and atherogenic profile in male Wistar rats administered anticancer drug Cisplatin

Background & Aim: This study was aimed at investigating the prophylactic effects of hydroethanolic extract of Ixora coccinea leaf (HEICL) on Cisplatin (cis diamminedichloroplatinum-II, CDDP)-induced alteration in atherogenic, haematological, and biochemical profiles in male Wistar rats Experimental: Thirty male rats were assigned into 6 groups (n=5) in which groups A, B, C, and D received normal saline (0.2 mL), CDDP (10 mg/kg), HEICL at 200 mg/kg, and HEICL at 400mg/kg. Groups E and F received CDDP 10 mg/kg with HEICL at 200 mg/kg, and 400 mg/kg, respectively. Results: The phytochemical analysis of the AEAC revealed the presence of some phytochemical constituents such as alkaloids, flavonoids, saponins, tannins, reducing sugar, phenol, resin, and volatile oil. However, glycosides, steroids, and anthraquinone were absent. The Acute toxicity result indicated that HEICL has an LD50 above 5000mg/kg. CDDP caused a significant (P