Hemorrhagic stroke and COVID-19 infection: Coincidence or causality?

Amyloid Protein Precursor gene duplication is a rare cause of early-onset Alzheimer's disease that can be associated with Cerebral Amyloid Angiopathy. This condition predisposes cerebrovascular events, specifically, intracerebral hemorrhagic stroke. This report describes a case of first-time intracerebral hemorrhage in a patient with APP gene duplication during SARS-CoV-2 infection, a typically pro-thrombotic and pro-inflammatory condition, as a possible trigger for this condition. •Stroke could be triggered by COVID-19 infection in high-risk patients.•Altered level of consciousness could be the first manifestation of COVID-19.•CT thorax scan must be considered during neuroimaging studies in stroke patients.