Mechanistic Study of Novel Dipeptidyl Peptidase IV Inhibitory Peptides from Goat's Milk Based on Peptidomics and In Silico Analysis

Two novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides (YPF and LLLP) were discovered from goat milk protein by peptidomics, in silico analysis, and in vitro assessment. A total of 698 peptides (

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Foods 2024-04, Vol.13 (8), p.1194
Hauptverfasser:	Wu, Yulong, Zhang, Jin, Zhu, Ruikai, Zhang, Hong, Li, Dapeng, Li, Huanhuan, Tang, Honggang, Chen, Lihong, Peng, Xinyan, Xu, Xianrong, Zhao, Ke
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Bonding strength Care and treatment computer simulation Diabetes Diabetes mellitus Dipeptidyl-peptidase IV Endopeptidase K Enzymes Ethylenediaminetetraacetic acid Food Functional foods Functional foods & nutraceuticals Glucose goat milk Goat's milk Hydrolysates inhibitory peptide LC-MS/MS Milk milk proteins Molecular docking peptidase K Peptidases Peptides peptidomics Physicochemical properties Polypeptides Proteinase Proteins Saxagliptin Sitagliptin Toxicity Type 2 diabetes virtual screening
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Two novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides (YPF and LLLP) were discovered from goat milk protein by peptidomics, in silico analysis, and in vitro assessment. A total of 698 peptides (
ISSN:	2304-8158 2304-8158
DOI:	10.3390/foods13081194