A Fatal Case of Pembrolizumab-Induced Myocarditis in Non–Small Cell Lung Cancer

Immune channel inhibitor–induced myocarditis is rare, and its management is challenging. Recently, guidelines were established for all ICIs, yet they do not take into account individual drug toxicities or screening protocols for prevention. We present a rare case of rapidly progressive pembrolizumab...

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Veröffentlicht in:JACC. Case reports 2020-03, Vol.2 (3), p.426-430
Hauptverfasser: Cohen, Max, Mustafa, Saim, Elkherpitawy, Islam, Meleka, Matthew
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Sprache:eng
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Zusammenfassung:Immune channel inhibitor–induced myocarditis is rare, and its management is challenging. Recently, guidelines were established for all ICIs, yet they do not take into account individual drug toxicities or screening protocols for prevention. We present a rare case of rapidly progressive pembrolizumab-induced fatal myocarditis in an initially asymptomatic patient. (Level of Difficulty: Beginner.) [Display omitted] Immune channel inhibitor–induced myocarditis is rare, and its management is challenging. Recently, guidelines were established for all ICIs, yet they…
ISSN:2666-0849
2666-0849
DOI:10.1016/j.jaccas.2019.12.045