Application of photodynamic therapy with 5-aminolevulinic acid and fractional CO2 laser for the management of recalcitrant plantar warts

•This study evaluates the effectiveness of combining fractional CO2 laser treatment with 5-aminolevulinic acid (5-ALA) photodynamic therapy (PDT) for the management of persistent plantar warts.•Our findings indicate that this combined treatment significantly clears skin lesions, demonstrating a high...

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Veröffentlicht in:Photodiagnosis and photodynamic therapy 2025-02, Vol.51, p.104407, Article 104407
Hauptverfasser: Chen, Jiaoquan, Xie, Xinyi, Liu, Yingxue, Chen, Fengyi, Gong, Yeqing, Liang, Bihua, Wu, Yiling, He, Shiqi, Li, Yueming, Zhu, Huilan, Ma, Shaoyin
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Sprache:eng
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Zusammenfassung:•This study evaluates the effectiveness of combining fractional CO2 laser treatment with 5-aminolevulinic acid (5-ALA) photodynamic therapy (PDT) for the management of persistent plantar warts.•Our findings indicate that this combined treatment significantly clears skin lesions, demonstrating a high rate of complete clearance.•The incidence of adverse events and recurrence of skin lesions among patients receiving this combined therapy is relatively low. Plantar warts, benign lesions on the soles of the feet, are caused by the human papillomavirus (HPV) infecting keratinocytes. Complete eradication of these warts is challenging, often leading to recurrences. This study evaluates the combined clinical efficacy of topical 5-aminolevulinic acid (5-ALA) photodynamic therapy (PDT) and fractional carbon dioxide (CO2) laser treatment for recalcitrant plantar warts. Data from 10 patients with recalcitrant plantar warts were analyzed. Initially, thickened hyperkeratotic tissue was removed using a super-pulsed CO2 laser. This was followed by fractional laser application, after which a 20 % 5-ALA cream was applied occlusively for 4 h. Patients then received He-Ne laser irradiation for 30 min at an energy density of 100 mW/cm², with treatments spaced 4 weeks apart. The study included 10 participants aged 24 to 53 years (mean age: 33.4 ± 8.09 years). In total, 40 lesions were treated across 1 to 9 PDT sessions, with an average of 5.2 ± 2.86 sessions per patient. Complete clearance was achieved in 3 patients (30 %), 4 patients (40 %) showed an excellent response (≥80 % improvement), while 2 patients had a partial response. One patient (10 %) showed
ISSN:1572-1000
1873-1597
1873-1597
DOI:10.1016/j.pdpdt.2024.104407