The critical role of endothelial function in fine particulate matter-induced atherosclerosis
Ambient and indoor air pollution contributes annually to approximately seven million premature deaths. Air pollution is a complex mixture of gaseous and particulate materials. In particular, fine particulate matter (PM ) plays a major mortality risk factor particularly on cardiovascular diseases thr...
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Veröffentlicht in: | Particle and fibre toxicology 2020-12, Vol.17 (1), p.61-24, Article 61 |
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Sprache: | eng |
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Zusammenfassung: | Ambient and indoor air pollution contributes annually to approximately seven million premature deaths. Air pollution is a complex mixture of gaseous and particulate materials. In particular, fine particulate matter (PM
) plays a major mortality risk factor particularly on cardiovascular diseases through mechanisms of atherosclerosis, thrombosis and inflammation. A review on the PM
-induced atherosclerosis is needed to better understand the involved mechanisms. In this review, we summarized epidemiology and animal studies of PM
-induced atherosclerosis. Vascular endothelial injury is a critical early predictor of atherosclerosis. The evidence of mechanisms of PM
-induced atherosclerosis supports effects on vascular function. Thus, we summarized the main mechanisms of PM
-triggered vascular endothelial injury, which mainly involved three aspects, including vascular endothelial permeability, vasomotor function and vascular reparative capacity. Then we reviewed the relationship between PM
-induced endothelial injury and atherosclerosis. PM
-induced endothelial injury associated with inflammation, pro-coagulation and lipid deposition. Although the evidence of PM
-induced atherosclerosis is undergoing continual refinement, the mechanisms of PM
-triggered atherosclerosis are still limited, especially indoor PM
. Subsequent efforts of researchers are needed to improve the understanding of PM
and atherosclerosis. Preventing or avoiding PM
-induced endothelial damage may greatly reduce the occurrence and development of atherosclerosis. |
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ISSN: | 1743-8977 1743-8977 |
DOI: | 10.1186/s12989-020-00391-x |