Use of edaravone to decrease perioperative neurocognitive disorders in elderly patients with hip replacement

[8] Evidently, the use of decreased scores of modified telephone interview alone for cognitive status to diagnose PND in this study cannot achieve the requirements of new recommendations for the definition of PND. [...]we question the incidence of PND reported in this study. [...]the duration of the hospital stay was shorter in the edaravone group than in the control group, but the authors did not provided the reasons for a prolonged hospital stay in the control group. [...]as a basic principle, in a randomized controlled trial, only an important observed parameter can be designed as the primary endpoint and sample size calculation must be performed on solely the primary endpoint.