A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy

Highlights An internal sub-nanostructural transformation of sub-nanostructural transformable gold@ceria (STGC-PEG) is initiated by the conversion between CeO 2 and electron-rich state of CeO 2−x , and active oxygen vacancies generation via the hot-electron injection from gold to ceria. The sub-nanos...

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Veröffentlicht in:Nano-Micro Letters 2022-12, Vol.14 (1), p.101-12, Article 101
Hauptverfasser: Hu, Xi, Wang, Nan, Guo, Xia, Liang, Zeyu, Sun, Heng, Liao, Hongwei, Xia, Fan, Guan, Yunan, Lee, Jiyoung, Ling, Daishun, Li, Fangyuan
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Sprache:eng
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Zusammenfassung:Highlights An internal sub-nanostructural transformation of sub-nanostructural transformable gold@ceria (STGC-PEG) is initiated by the conversion between CeO 2 and electron-rich state of CeO 2−x , and active oxygen vacancies generation via the hot-electron injection from gold to ceria. The sub-nanostructural transformation of STGC-PEG enhances the peroxidase-like activity and activates the plasmon-promoted oxidase-like activity, resulting in an augmented reactive oxygen species output. STGC-PEG successfully achieves excellent low power (50 mW cm −2 ) near-infrared light-activated photocatalytic ablation of tumors in vivo. The structural change-mediated catalytic activity regulation plays a significant role in the biological functions of natural enzymes. However, there is virtually no artificial nanozyme reported that can achieve natural enzyme-like stringent spatiotemporal structure-based catalytic activity regulation. Here, we report a sub-nanostructural transformable gold@ceria (STGC-PEG) nanozyme that performs tunable catalytic activities via near-infrared (NIR) light-mediated sub-nanostructural transformation. The gold core in STGC-PEG can generate energetic hot electrons upon NIR irradiation, wherein an internal sub-nanostructural transformation is initiated by the conversion between CeO 2 and electron-rich state of CeO 2− x , and active oxygen vacancies generation via the hot-electron injection. Interestingly, the sub-nanostructural transformation of STGC-PEG enhances peroxidase-like activity and unprecedentedly activates plasmon-promoted oxidase-like activity, allowing highly efficient low-power NIR light (50 mW cm −2 )-activated photocatalytic therapy of tumors. Our atomic-level design and fabrication provide a platform to precisely regulate the catalytic activities of nanozymes via a light-mediated sub-nanostructural transformation, approaching natural enzyme-like activity control in complex living systems.
ISSN:2311-6706
2150-5551
2150-5551
DOI:10.1007/s40820-022-00848-y