Caries preventing efficacy of new Isomalt-containing mouthrinse formulations: a microbial study

Objectives The effectiveness of an Isomalt-containing mouthrinse to prevent caries development was investigated. Methods Human enamel blocks were randomly assigned to five groups ( n  = 30/group): De-ionized distilled water (DDW), and mouthrinse containing either (IFC) 1% Isomalt, 225 ppm fluoride,...

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Veröffentlicht in:BDJ open 2024-06, Vol.10 (1), p.51-7
Hauptverfasser: Amaechi, Bennett T., AbdulAzees, Parveez Ahamed, Mohseni, Sahar, Luong, Minh N., Lin, Chun-Yen, Restrepo-Ceron, Maria Camila, Kataoka, Yuko, Omosebi, Temitope O., Kanthaiah, Kannan
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Sprache:eng
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Zusammenfassung:Objectives The effectiveness of an Isomalt-containing mouthrinse to prevent caries development was investigated. Methods Human enamel blocks were randomly assigned to five groups ( n  = 30/group): De-ionized distilled water (DDW), and mouthrinse containing either (IFC) 1% Isomalt, 225 ppm fluoride, and 0.05% cetylpyridinium chloride (CPC), (IF) 1% Isomalt and 225ppm fluoride, (FC) 225 ppm fluoride and 0.05% CPC or (F) 225 ppm fluoride. During 7-day demineralization in a Microbial Caries Model, mouthrinses were applied once daily for 1 min. Demineralization was assessed using Surface Microhardness testing for percentage change in SMH (%ΔSMH) and Transverse Microradiography for mineral loss (ΔZ). Data analysis (α = 0.05) used paired t-test (Intra-group comparison using SMH) and ANOVA/Tukey’s for inter-group comparisons (%ΔSMH and ΔZ). Results With SMH, relative to sound enamel baseline, demineralization was significant ( P  
ISSN:2056-807X
2056-807X
DOI:10.1038/s41405-024-00241-4