The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187

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Veröffentlicht in:	Haematologica (Roma) 2009-12, Vol.94 (12), p.1783-1784
Hauptverfasser:	Leytin, Valery, Mutlu, Asuman, Mykhaylov, Sergiy, Allen, David J, Gyulkhandanyan, Armen V, Freedman, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Blood Platelets - cytology Blood Platelets - drug effects Blood Platelets - metabolism Calcimycin - pharmacology Caspase 3 - metabolism Coagulants - pharmacology Enzyme Activation - drug effects Flow Cytometry Humans Ionophores - pharmacology Letters to the Editor Peptides - pharmacology Platelet Aggregation Inhibitors - pharmacology Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors Thrombin - pharmacology Tyrosine - analogs & derivatives Tyrosine - pharmacology
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