Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF

The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way toward the extended use of Sc(III)-based MOFs as drug delivery systems (DDSs). [Display omitted] •MFM-300(Sc) presents good stability and biocompatibility•FER@MFM-300(Sc) allows the long-term transdermal release of ferulate (FER–)•FER@MFM-300(Sc) prevents the photodegradation of FER Medicine; Chemistry; Inorganic Chemistry; Materials Structure