High-dose intravenous vitamin C reduces urinary tract infection post-kidney transplantation

Background Urinary tract infection (UTI) accounts for about half of all post- kidney transplant infections. There is conflicting data regarding vitamin C and UTI prevention. So far, its efficacy has not been studied in renal transplant patients. Methods Kidney transplant candidates were randomized between vitamin C and placebo arms. In the treatment group, patients received vitamin C infusion at a single dose of 70 mg/kg. In another study arm, only the diluent solution was administered. Data regarding bacteriuria during the first hospitalization after transplantation were recorded. Results A total of 19 patients were randomized to the placebo ( n = 10) and vitamin C ( n = 9) group. The rate of bacteriuria during the first hospitalization after transplantation was significantly lower in the vitamin C group than in the placebo group, 11.1% versus 60%, respectively. ( P = 0.02). Conclusion Vitamin C as a safe treatment is a potential prophylactic agent in post kidney transplantation UTI.