Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction

Plaque erosion causes 30% of ST-segment elevation myocardial infarctions, but the underlying cause is unknown. Inflammatory infiltrates are less abundant in erosion compared with rupture in autopsy studies. We hypothesized that erosion and rupture are associated with significant differences in intra...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Heart Association 2017-05, Vol.6 (5)
Hauptverfasser:	Chandran, Sujay, Watkins, Johnathan, Abdul-Aziz, Amina, Shafat, Manar, Calvert, Patrick A, Bowles, Kristian M, Flather, Marcus D, Rushworth, Stuart A, Ryding, Alisdair D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers - blood Coronary Angiography coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - complications Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - therapy Cytokines - blood Cytokines - genetics Enzyme-Linked Immunosorbent Assay Epidermal Growth Factor - blood erosion Female Fibrosis Gene Expression Profiling - methods Humans inflammation Inflammation Mediators - blood Male Middle Aged myocardial infarction Oligonucleotide Array Sequence Analysis optical coherence tomography Original Research Percutaneous Coronary Intervention Plaque, Atherosclerotic Prospective Studies Real-Time Polymerase Chain Reaction Risk Factors Rupture, Spontaneous ST Elevation Myocardial Infarction - blood ST Elevation Myocardial Infarction - diagnostic imaging ST Elevation Myocardial Infarction - etiology ST Elevation Myocardial Infarction - therapy Thrombectomy thrombospondin 1 Thrombospondin 1 - blood Tomography, Optical Coherence
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Plaque erosion causes 30% of ST-segment elevation myocardial infarctions, but the underlying cause is unknown. Inflammatory infiltrates are less abundant in erosion compared with rupture in autopsy studies. We hypothesized that erosion and rupture are associated with significant differences in intracoronary cytokines in vivo. Forty ST-segment elevation myocardial infarction patients with
ISSN:	2047-9980 2047-9980
DOI:	10.1161/JAHA.117.005868