A New Megastigmane Glucoside and Other Constituents from Desmodium gangeticum

A New Megastigmane Glucoside and Other Constituents from Desmodium gangeticum

A new megastigmane glycoside, gangeticoside (1), and three known compounds leonuriside A (2), methyl benzoate 2-O-β-D-glucopyranoside (3), and tortoside A (4) were isolated from the aerial part of Desmodium gangeticum. Their structures were determined by 1D and 2D NMR spectra. The isolated compounds...

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Veröffentlicht in:Journal of chemistry 2020-11, Vol.2020 (2020), p.1-4
Hauptverfasser: Dat, Nguyen Tien, Ngo, Phuong Thi, Do, Giang Hoang, Dang, Hau Viet, Le, Ha Minh
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Benzoates
Carbon
Chromatography
Esters
Glucose
NMR
Nuclear magnetic resonance
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Zusammenfassung:A new megastigmane glycoside, gangeticoside (1), and three known compounds leonuriside A (2), methyl benzoate 2-O-β-D-glucopyranoside (3), and tortoside A (4) were isolated from the aerial part of Desmodium gangeticum. Their structures were determined by 1D and 2D NMR spectra. The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. Among them, compounds 1, 2, and 3 exhibited strong effect with the IC50 values of 22.3, 15.6, 7.3 μM, respectively.
ISSN:2090-9063
2090-9071
DOI:10.1155/2020/7416973