CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson’s disease

In an alpha-synuclein (α-syn) model of Parkinson’s disease (PD), Schonhoff and colleagues have shown that central nervous system (CNS)-associated macrophages (CAMs), but not microglia, potentially orchestrate CD4 + T cell recruitment and mediate an α-syn-induced inflammatory makeup.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature communications 2023-06, Vol.14 (1), p.3753-3753, Article 3753
Hauptverfasser:	Frosch, Maximilian, Amann, Lukas, Prinz, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1689/1718 631/378/2596 Alzheimer's disease Animals Antigen presentation Brain CD4 antigen Cells Central nervous system Comment Cytokines Disease Models, Animal Flow cytometry Genes Humanities and Social Sciences Inflammation Inflammatory response Lymphocytes Lymphocytes T Macrophages Mice Microglia Movement disorders multidisciplinary Neurodegenerative diseases Parkinson Disease Parkinson's disease Physiology Science Science (multidisciplinary) Synuclein
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Beschreibung
Zusammenfassung:	In an alpha-synuclein (α-syn) model of Parkinson’s disease (PD), Schonhoff and colleagues have shown that central nervous system (CNS)-associated macrophages (CAMs), but not microglia, potentially orchestrate CD4 + T cell recruitment and mediate an α-syn-induced inflammatory makeup.
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-023-39061-9