Achillea millefolium L. and Achillea biebersteinii Afan. Hydroglycolic Extracts-Bioactive Ingredients for Cosmetic Use
Studies on hydroglycolic (HG) extracts of (AB)-a less investigated representative of the genus-were performed to determine their potential for cosmetic applications compared to the well-known (AM). Three types of water:polyethylene glycol extracts (1:1, 4:1, 6:1 / ) were obtained from both species a...
Gespeichert in:
Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2020-07, Vol.25 (15), p.3368 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Studies on hydroglycolic (HG) extracts of
(AB)-a less investigated representative of the genus-were performed to determine their potential for cosmetic applications compared to the well-known
(AM). Three types of water:polyethylene glycol extracts (1:1, 4:1, 6:1
/
) were obtained from both species and analyzed for their composition by high performance liquid chromatography coupled with mass spectrometry (HPLC-ESI-Q-TOF-MS) and assayed for their biological activities. The study led to the identification of 11 metabolites from different natural product classes with the highest share corresponding to 5-caffeoylquinic acid, axillarin, coumaroylquinic acid isomers and 3-caffeoylquinic acid. The highest antiradical capacity in DPPH and ABTS scavenging assays was shown for HG 4:1 of AB and AM extracts. HG 1:1 extracts from both species inhibited monophenolase and diphenolase activity of tyrosinase, whereas AB HG 4:1 extract showed significant monophenolase inhibition. The highest sun protection factor (SPF) was determined for AM HG 4:1 extract, equal to 14.04 ± 0.17. The AB extracts were cytotoxic for both human keratinocytes HaCaT and A375 melanoma, however HG 1:1 and 4:1 extracts were more cytotoxic for cancer than for noncancerous cells. In conclusion, AB HG 1:1 and 4:1 extracts display significant potential as active cosmetic ingredients. |
---|---|
ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules25153368 |