Cancer-associated fibroblast-related prognostic signature predicts prognosis and immunotherapy response in pancreatic adenocarcinoma based on single-cell and bulk RNA-sequencing

Cancer-associated fibroblast-related prognostic signature predicts prognosis and immunotherapy response in pancreatic adenocarcinoma based on single-cell and bulk RNA-sequencing

Cancer-associated fibroblasts (CAFs) influence many aspects of pancreatic adenocarcinoma (PAAD) carcinogenesis, including tumor cell proliferation, angiogenesis, invasion, and metastasis. A six-gene prognostic signature was constructed for PAAD based on the 189 CAF marker genes identified in single-...

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Veröffentlicht in:Scientific reports 2023-09, Vol.13 (1), p.16408-16408, Article 16408
Hauptverfasser: Chen, Yajun, Deng, Qican, Chen, Hui, Yang, Jianguo, Chen, Zhenzhou, Li, Juncai, Fu, Zhongxue
Format: Artikel
Sprache:eng
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Adenocarcinoma
Adenocarcinoma - genetics
Adenocarcinoma - therapy
Angiogenesis
Beta cells
Calcium channels (voltage-gated)
Cancer
Cancer-Associated Fibroblasts
Carcinogenesis
CD8 antigen
Cell proliferation
Fibroblasts
Humanities and Social Sciences
Humans
Immunotherapy
Infiltration
Medical prognosis
Metastases
multidisciplinary
Pancreas
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - therapy
Prognosis
Risk groups
RNA
Science
Science (multidisciplinary)
Tumor Microenvironment - genetics
Tumors
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Zusammenfassung:Cancer-associated fibroblasts (CAFs) influence many aspects of pancreatic adenocarcinoma (PAAD) carcinogenesis, including tumor cell proliferation, angiogenesis, invasion, and metastasis. A six-gene prognostic signature was constructed for PAAD based on the 189 CAF marker genes identified in single-cell RNA-sequencing data. Multivariate analyses showed that the risk score was independently prognostic for survival in the TCGA (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-43495-y