Diisoprenyl Cyclohexene-Type Meroterpenoids with Cytotoxic Activity from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y85

Five new diisoprenyl cyclohexene-type meroterpenoids, aspergienynes J-N ( - ), along with three known analogues ( - ), were obtained from the mangrove endophytic fungal strain sp. GXNU-Y85. The chemical structures, including their absolute configurations, were established via spectroscopic data and...

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Veröffentlicht in:	Marine drugs 2024-01, Vol.22 (2), p.58
Hauptverfasser:	Qin, Feng, Song, Zi-Shuo, Luo, Li, Bo, Xiang-Long, Wu, Fu-Rong, Tan, Mei-Jing, Wang, Fan-Fan, Huang, Xi-Shan, Wang, Heng-Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-cancer activity Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Apoptosis Aspergillus Aspergillus - chemistry Aspergillus sp Cancer Carbon Cell cycle Cells Cyclohexene Cytotoxicity Endophytes Flow cytometry Fungi HeLa Cells Humans mangrove endophytic fungus Mangroves meroterpenoids Metabolites Molecular Structure Spectrum Analysis Toxicity
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Zusammenfassung:	Five new diisoprenyl cyclohexene-type meroterpenoids, aspergienynes J-N ( - ), along with three known analogues ( - ), were obtained from the mangrove endophytic fungal strain sp. GXNU-Y85. The chemical structures, including their absolute configurations, were established via spectroscopic data and comparison of experimental and calculated ECD spectra. Cytotoxicity assay results indicated that compound had strong cytotoxicity against HeLa cancer cells, and its IC value was 11.8 μM. In addition, flow cytometry analysis revealed that the cytotoxicity of was due to the induction of G1 cell cycle arrest and apoptosis in HeLa cells.
ISSN:	1660-3397 1660-3397
DOI:	10.3390/md22020058