Effect of Different Intrauterine Oxytetracycline Treatment on Reproductive Performance of Dairy Cows with Clinical Endometritis and Determination of Oxytetracycline Residues in Milk

Main objective of this study was to determine whether intrauterine infusion of oxytetracycline (OTC) is an appropriate method for the treatment of postpartum endometritis in dairy cows or not. To this end, 280 lactating Holstein cows with clinical signs of endometritis were randomly assigned into three treatment groups and 186 cows were sampled for cytology experiment. In group 1 (n=73) cows were treated with intrauterine infusion of 5 g/cow 10% OTC. In group 2 (n=44), before intrauterine OTC treatment, caudal epidural anesthesia was used to eliminate straining. In group 3 (n=49) after intrauterine infusion of 5g/cow 10% OTC, 100 ml of normal saline was injected to reduce the concentration of OTC and 20 untreated cows were assigned into control group (group 4). Clinical treatment rates were 79.4%, 68.1%, 65.3 %and 50% in OTC, OTC and caudal epidural anesthesia (OTC+CEA), OTC+Serum and control groups, respectively (P>0.05). Cytological treatment rate in each experiment group was significantly higher than the cytological treatment rate in control group in the second examination (P