Bone mineral density and risk of type 2 diabetes and coronary heart disease: A Mendelian randomization study

Bone mineral density and risk of type 2 diabetes and coronary heart disease: A Mendelian randomization study

Observational studies have demonstrated that increased bone mineral density is associated with a higher risk of type 2 diabetes (T2D), but the relationship with risk of coronary heart disease (CHD) is less clear. Moreover, substantial uncertainty remains about the causal relevance of increased bone...

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Veröffentlicht in:Wellcome open research 2017, Vol.2, p.68-68
Hauptverfasser: Gan, Wei, Clarke, Robert J, Mahajan, Anubha, Kulohoma, Benard, Kitajima, Hidetoshi, Robertson, Neil R, Rayner, N William, Walters, Robin G, Holmes, Michael V, Chen, Zhengming, McCarthy, Mark I
Format: Artikel
Sprache:eng
Schlagworte:
Bone Biology, Osteoporosis & Other Diseases of Bone
Bone density
Cardiovascular disease
Causality
Coronary Artery Disease
Diabetes
Health risk assessment
Insulin resistance
Pancreas
Studies
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Zusammenfassung:Observational studies have demonstrated that increased bone mineral density is associated with a higher risk of type 2 diabetes (T2D), but the relationship with risk of coronary heart disease (CHD) is less clear. Moreover, substantial uncertainty remains about the causal relevance of increased bone mineral density for T2D and CHD, which can be assessed by Mendelian randomisation studies.  We identified 235 independent single nucleotide polymorphisms (SNPs) associated at
ISSN:2398-502X
2398-502X
DOI:10.12688/wellcomeopenres.12288.1