Oral and uterine leiomyomas exhibit high immunoexpression of Cripto-1 compared to normal myometrium

Oral and uterine leiomyomas exhibit high immunoexpression of Cripto-1 compared to normal myometrium

Leiomyomas are the most common benign tumors in women. Many of them are associated with significant morbidity. The present study aimed to analyze histomorphological and histochemical characteristics and immunoexpression of Cripto-1 in oral leiomyomas (OL), uterine leiomyomas (UL), and normal myometr...

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Veröffentlicht in:Anais da Academia Brasileira de Ciências 2020-01, Vol.92 (4), p.e20200519-e20200519
Hauptverfasser: Silva, AndrÉ F, Silva, Emmily C C DA, Oliveira, ClÁudia N, Rocha, Keyla B F, Miguel, Marcia C C, Pereira, Joabe S
Format: Artikel
Sprache:eng
Schlagworte:
Cripto-1
Female
Humans
Immunohistochemistry
Leiomyoma
MULTIDISCIPLINARY SCIENCES
Myometrium
Neoplasia
Uterine Neoplasms
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Zusammenfassung:Leiomyomas are the most common benign tumors in women. Many of them are associated with significant morbidity. The present study aimed to analyze histomorphological and histochemical characteristics and immunoexpression of Cripto-1 in oral leiomyomas (OL), uterine leiomyomas (UL), and normal myometrium (NM). Sample was composed of ten OL, 11 UL and 11 NM. Histomorphological characteristics were analyzed at 100 and 400x magnifications with HE staining. The immunoexpression of Cripto-1 was analyzed in five high-power fields. Statistical analysis considered a significant difference when p
ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765202020200519